I think the thermovalve just lowers the idle of the engine once it's warmed up, therefore reducing emissions or something. I think it's safe to disconnect as long as you plug the feed line so there is no vacuum leak, and then you may have to adjust the idle speed slightly.

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1967 W110 Universal Wagon, Euro, Turbo Diesel, Tail Fins, 4 Speed Manual Column Shift, A/C
1980 W116 300SD Turbo Diesel, DB479 Walnut Brown, Sunroof, Highly Optioned, 350,000+ Miles