In my opinion E class cars are some of the best with the main thing being proper, routine maintenance. Not knowing where you live, shop cost, and mileage you drive I can't predict your cost but if you budget $100/month you should be fine. Just don't try to save money by not doing correct and proper service.

This is only in reference to the mechanical side of things, engine, tranny and drivetrain. Too early to tell on items like navigation screen and the bs electronic entertainment stuff. Now where did I put my paper map? 20 years from now no one will be able to use a paper map to figure out where to go.

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Jim