I just bought a '94 S320 for my wife, what a rock on the road. It's a very comfortable and solid car. Plenty of pickup for a car that size. It also has good road feel. It's a bit bigger and heavier that my 300D, but on a long trip it sure is nice.

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1983 300D Silver -mine- 185,000 w/ donor transmission
1983 300D Gray (Franklin) -parts car- 180,000- no transmission and no oil pan
1994 S320 Silver -wife's-135,000