I use these all of the time here at work...I program PDA devices and CF cards are the norm.

Other than probably requiring a driver, it's plug and play.

Actually, Windows XP supports many USB-compatible devices with it's own drivers, so it's even simpler.

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2009 ML350 (106K) - Family vehicle
2001 CLK430 Cabriolet (80K) - Wife's car
2005 BMW 645CI (138K) - My daily driver
2016 Mustang (32K) - Daughter's car