In my 300CD with a used passenger door actuator and a new primary vacuum valve (on the drivers door) I can lock and unlock about 4 sometimes 5 times before the vacuum is gone.

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'84 300CD Turbo 132k (Anthracite Grey) - WVO - My daily driver - Recently named coo-coo-coupe by my daughter.
'84 300D Turbo 240k (Anthracite Grey) - Garage Queen
'83 300D Turbo 220k (Orient Red) - WVO - Wifes daily driver

I'm not a certified mechanic, but I did stay at a HolidayInn Express last night.