Your correct about the airplane nose being 22 degrees off the centerline of the runway in the example you gave. The trick is to get the nose back inline with the runway prior to touchdown by using a combination of the rudder and ailerons on the wings.

Back to the question that started this thread, noise is a big factor these days on determining which runway is used. I fly cargo planes in the middle of the night , and we are often faced with landing with less than favorable winds in order to avoid noise sensitive areas.