Not sure what chassis we're talking about here but if it's anything like the 124, i'd say the window motors are shot.

Easy way to check is to pull one of the door panels off and put a voltmeter across the motor contacts, they are accessible without removing the motor on a 124 door, ymmv

If you get power when you press the switch, the motor's at fault. If there's no power, check the fuses.

Plenty of posts here on this subject, try a search.

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1987 300e manual 250,000 km (sold)