I drive my 96 S500 Coupe M119 about 130 miles every day (about 65 miles each way to work). Parts of the commute are 70 mph and parts are bumper to bumper at a crawl. Takes me easily 4 hours a day on the road. Gotta love this Washington DC traffic!
My gas mileage is 21 mpg combined... every time.
I've gotten mid to upper 20's on a long trip.
Not bad for a heavy car with over 300 hp.