Certainly, provided you are equipped to work underneath the vehicle safely.

1) Good, sturdy jack stands!
2) Good, sturdy floor jack!
3) Good, methodical approach!

In my area a good quality rebuilt MB transmission runs between $1500.00 and $2200.00, including rebuilt converter. If I install the transmission the average expense to the vehicle owner is approximately $630.00 (+ Haz Mat).

You will more than likely spend 6 to 8 hours flat backing the transmission exchange excluding the final adjustments. The questions to ask yourself may be “how much time and energy am I willing to expend to say I replaced the transmission?” or “how much is my time worth?”

Should you decide to replace the tranmission yourself I am certain that a number of people in this forum will be more than willing to assist you with the task.