I've been playing around with Safari 4 and I really like it. It handles AJAX websites such as facebook really well and the rendering is a lot better than Firefox's.

My only complaint is that there isn't an equivalent of Adblock Plus for it. I can't stand to surf the internet with all of the advertisements that adblock plus removes.

Does anyone know of a program that does this?

http://burgersoftware.com/en/safariadblock

Google comes up with that, but running Safari in 64bit mode is what makes it run so well.
I've also heard of a program that updates the hosts files on computers to block ads for every browser on a computer.

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-Typos courtesy of my mobile phone.