Common denominator seems to be the car. Resting battery voltage seems fine. Both the unpowered RFID function (car start) as well as the powered RF (door open) stop working at about the same time. Batteries in key are new also (even though that would have no affect on the car starting function). Have another key and it doesn't work either. Is there a central computer to blame?

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1998 C230 330,000 miles (currently dead of second failed EIS, yours will fail too, turning you into the dealer's personal human cash machine)
1988 F150 144,000 miles (leaks all the colors of the rainbow)
Previous stars: 1981 Brava 210,000 miles, 1978 128 150,000 miles, 1977 B200 Van 175,000 miles, 1972 Vega (great, if rusty, car), 1972 Celica, 1986.5 Supra

If you've got two keys and neither of them work, the Electronic Ignition Switch (EIS)is probably at fault. Not a DIY job, and not a job for an indy unless he's equipped with SDS, and is familiar with this particular job.

Today I got to work, got out of the car and the key would not lock the doors. I tried and tried. I then opened the door and checked the car battery resting voltage which was 13.3. I put the key in the ignition and the steering unlocked as normal, I then turned the key one click and then back and removed it. I then closed the door and the doors locked fine. Don't know what to make of this.

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1998 C230 330,000 miles (currently dead of second failed EIS, yours will fail too, turning you into the dealer's personal human cash machine)
1988 F150 144,000 miles (leaks all the colors of the rainbow)
Previous stars: 1981 Brava 210,000 miles, 1978 128 150,000 miles, 1977 B200 Van 175,000 miles, 1972 Vega (great, if rusty, car), 1972 Celica, 1986.5 Supra

The EIS does a lot of things. It validates the lock/unlock signals from your remote keys. It reads information from the key when it's inserted and allows the steering column to unlock. It then receives a message from the steering lock motor and allows the key to be turned to the crank position. Then, it releases drive authorization data to the engine control module, which allows the starter and fuel pump to work. The fact that your issue is intermittent doesn't surprise me one bit.

Today same as yesterday. Door wouldn't lock with repeated tries. So I opened door, put key in ignition, turned, removed, shut door. Then it locked the first try.

__________________
1998 C230 330,000 miles (currently dead of second failed EIS, yours will fail too, turning you into the dealer's personal human cash machine)
1988 F150 144,000 miles (leaks all the colors of the rainbow)
Previous stars: 1981 Brava 210,000 miles, 1978 128 150,000 miles, 1977 B200 Van 175,000 miles, 1972 Vega (great, if rusty, car), 1972 Celica, 1986.5 Supra