Have the throttle actuator and upper harness been changed out with post 1998 replacements? When were the coils and plugs last changed?

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Those issues should be addressed, but they're not the problem here. If they were, the car would be lurching forward as if under firm acceleration when the engine RPM spikes.

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Current stable:
1995 E320 157K (Nancy)
1983 500SL 125K (SLoL)

Gone but not forgotten:
1986 300SDL (RIP)
1991 350SD
1991 560SEL
1990 560SEL
1986 500SEL Euro (Rusted to nothing at 47K!)

Gone and wanting to forget:
1985 524TD 167K (TotalDumpster™) [Definitely NOT a Benz]