Which engine are you thinking of...?
OM.606.962 has an Electronically controlled Mechanical fuel-injection-pump, an engine ECU and various sensors,--For tuning above about 220BHP, the pump needs modding anyway.
Prob is, It comms with the 722.6xx gearbox, and its ECU via CAN-BUS (Never heard of Manual E300TD W210) --So you gotta fit the box as well as its ECU--which mechanically is prolly simpler, but an electronic nightmare...
Now, whether the pair of ECU's comms with any 'Body related' ECU's as well, such as ABS, SRS, elect dashboard, etc, etc--Who knows!
I have heard of someone who fitted a Sprinter engine to a car (W201?) with all its ECU's etc, but cant 'break the Immobiliser'
--Maybe there's other issues with it too, I dunno...
Easiest way is drop the electronics and tune it mechanically, Thats what the Finns and others do....
Later Coomon-Rail Direct-Injection engines ain't as tuneable allegedly and you have all the issues above...