There is a sort of urban legend that the .22 has killed more than any other caliber, or something. I don't know if there's any truth to it, but you hear it all the time. FBI recently released 2010 stats on LEOs killed in action. Most frequent caliber was .38sp and .40.
I really don't like shooting .40, way too snappy and hard to control. I fooled around with cutting powder weights way down on .40 reloads to the bare minimum that would cycle a pistol I had. Still didn't like it.

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