Is it the supply line or return line? Is there a threaded fitting on one end or clamps on both ends? In either case, the only pressure should be from the weight of the fuel in the tank. If it is the supply line, I would drain the tank and clean the strainer at the same time I replaced the hose. If it's the return line, get a helper to plug the nipple from the tank while you replace the hose.

In fact, if the hoses are original, I would replace them all on principle.