There was a show on last night on pbs about the ballistics of the kennedy shooting. The rifle used was a little known 6.5 mm which had a very heavy bullet for the size of the bore. They tested it different ways but the thing that really impressed me was they shot it into a stack of 3/4" pine boards bookended on a table and it penetrated about 36" of pine with very little veering off and the bullet was nearly in perfect condition when they dug it out of the board it came to rest in.
I think that shows the viability of the one bullet theory.
I did not watch the whole show. (There was a new pickers on too

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[SIGPIC] Diesel loving autocrossing grandpa Architect. 08 Dodge 3/4 ton with Cummins & six speed; I have had about 35 benzes. I have a 39 Studebaker Coupe Express pickup in which I have had installed a 617 turbo and a five speed manual.

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..I also have a 427 Cobra replica with an aluminum chassis.