Synthetic auto transmission fluid

Calling all techs and engineers!
Since the time is drawing near when I again must change my transmission fluid, and having seen a synthetic version on the shelves recently, I've been wondering if it's worth the switch. I don't think there's much of a cost vs. benefit issue here, even though the synthetic stuff is 2-3x the price of the mineral version, since the ultimate retail price is still a pittance for a service performed once every year or two. Rather, is there a technical benefit to be had for the typical driver? Is there a downside to switching to synthetic after thousands of kilometers of using the standard stuff?
Appreciate any and all comments.
Regards,
Nick