Depends what you want. Driven both the W210 is simply a quiter, faster, more comfortable car. Pretty much what you would expect from a more modern design.

The E300D would be a great driver. The 300D is a garage queen/weekend toy.

What are you looking for?

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2006 CL500
2009 C300 4matic
1969 280SE
2023 Ram 1500
2007 Tiara 3200