W211 acceleration blues

[thesupernge]

Hey folks,
I'm a semi-regular on the 911 forum but this is my first post here. I have a 2006 E350 that is having some low-speed acceleration issues. It is hesitating when pushed past idle speed. It almost feels like a miss but there are zero codes in the system.
If the car had a carb, I'd probably say it was dirty fuel or crap somewhere in the system. With EFI I am a bit lost. Does it make sense to start with the fuel filter and work my way forward? If yes, does anyone have a good fuel filter R&R guide?
Thanks guys!